ABSTRACT
Majority of the Sclerosing stromal tumours of the ovary documented in the literature are single case reports. We report a series of 4 cases. Among the 4 cases encountered the mean age at presentation was 22.2 years. The clinical presentation varied from asymptomatic mass per abdomen (2 cases), menorrhagia (1 case) and amenorrhoea (1 case). The tumour was unilateral in all the cases with an average size of 10 cms. Grossly the appearances varied from a solid, partly cystic, edematous tumour (2 cases) to solid,firm tumour with yellow flecks (1 case) to unilocular cystic tumour (1 case). Microscopically, the tumour was characterized by cellular pseudolobules composed of a disorderly admixture of collagen-producing fibroblasts and lipid rich lutein cells with shrunken nuclei. In one case the lutein cells had a robust appearance with abundant cytoplasm and vesicular nuclei. The pseudolobules were very vascular and separated by hypocellular dense to oedematous fibrous tissue. Frozen section demonstrated fat in luteinized cells in 3 cases.
Subject(s)
Adult , Female , Humans , Ovarian Neoplasms/pathology , Ovary/pathology , Sex Cord-Gonadal Stromal Tumors/pathologyABSTRACT
Prolymphocytic leukaemia is a rare subtype of chronic lymphocytic leukaemia. Three such cases are reported here along with clinical details. All these cases were seen in males above 5th decade of life. These patients showed moderate to massive splenomegaly, inconspicuous lymphadenopathy in two cases and one with minimal lymphadenopathy. Peripheral smear showed high leucocyte count with more than 55% of prolymphocytes. Bone marrow aspiration showed diffuse involvement; and in one with minimal lymphadenopathy, lymph node aspiration showed prolymphocytes. All the three patients died within a year after diagnosis.
Subject(s)
Aged , Antineoplastic Agents/therapeutic use , Diagnosis, Differential , Fatal Outcome , Humans , Leukemia, Prolymphocytic/diagnosis , Male , Middle AgedABSTRACT
T-Cell-Rich B-Cell lymphoma (TCRBCL) is a recently described variant of diffuse large B-cell lymphoma characterized by a predominance of reactive T-cells and a minority of neoplastic large cells which may resemble the Reed-Sternberg cell or its variants. TCRBCL is a notorious mimicker of both lymphocyte predominance Hodgkin's disease (LPHD) and peripheral T-cell lymphoma (PTCL). Immunohistochemistry is mandatory for a definitive diagnosis. We report a case of TCRBCL which was mistaken for HD both on fine needle aspiration cytology and histopathology due to the presence of RS like cells. Immunohistochemistry resolved the diagnostic dilemma.
Subject(s)
Adult , Antigens, CD/metabolism , Diagnosis, Differential , Hodgkin Disease/diagnosis , Humans , Immunohistochemistry , Lymphoma, B-Cell/diagnosis , Lymphoma, Large B-Cell, Diffuse/diagnosis , Male , T-Lymphocytes/immunologyABSTRACT
Prolymphocytic leukaemia is a rare subtype of chronic lymphocytic leukaemia. Three such cases were reported here along with clinical details. All these cases were seen in males above 5th decade. These patients showed moderate to massive splenomegaly, inconspicuous lymphadenoapthy in two cases and one with minimal lymphadenopathy. Peripheral smear showed high leukocyte count with more than 55% of prolymphocytes. Bone marrow aspiration showed diffuse involvement and in one with minimal lymphadenopathy, lymphnode aspiration showed prolymphocytes. All the three patients died within a year after diagnosis.